Pop open the Format Cells dialog box with all the familiar tabs, like Number, Alignment and Border by using Ctrl+1. This shortcut works on a cell or a single selected word within a cell.
Change the font to Strikethrough with the Ctrl+5 shortcut. This also works on a cell or a single selected word within a cell.
Hide a column without selecting it by hitting Ctrl+0. No need to mouse and click to hide a whole column in a work sheet with this.