If you have a signature set added to each email and each response, an email thread might have your signature multiple times! If you’re using graphics and multiple lines of contact info, this can get tedious for your recipients.
Be sure your default signature for replies/forwards is set to (none). The first time you reply to an email, you can add your signature by clicking on the Signatures button, Message tab in the Include group. That way, the recipient gets your contact info the first time, but not every time!